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Which contains more caffeine: pre-workout supplements or energy drinks? When we compare pre-workout supplements with energy drinks, the caffeine levels can vary widely. Most energy drinks usually have around 80–150 mg of caffeine per can, which gives quick stimulation and some energy drink benefits like alertness and reduced fatigue. On the other hand, the best pre-workout products often contain higher caffeine levels, sometimes 200–300 mg per serving, as they are designed for intense training sessions. Conclusion: If you need a mild boost, energy drinks are enough, but for high-performance training, a pre-workout supplement usually contains more caffeine and gives a stronger effect.